| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | , | for | Yates, LA, IR | Released from injured reserve | Jun 9 | 13:48 |
| James | Abel, Phi, P | for | Rea, Mil, P | Free Replacement | Jun 7 | 15:08 |
| James | Kiner-Falefa, Pit, SS | for | Tovar, Col, SS → IR | DL | Jun 7 | 15:06 |
| John | Kelly, Ari, C | for | Ruiz, Was, C | Free Replacement | Jun 4 | 14:07 |
| James | Durbin, Mil, 3B | for | Toglia, Col, 1B | Minors | Jun 4 | 13:05 |
| Ben | Gallen, Ari, P | for | Meyer, Mia, P | DL | Jun 4 | 12:57 |
| Ben | Nelson, Ari, P | for | Burnes, Ari, P → IR | DL | Jun 3 | 21:32 |
| James | , | for | Smith-Shawver, Atl, IR | Released from injured reserve | Jun 3 | 10:35 |
| John | Patrick, Mil, P | for | Henderson, Mil, P | Minors | Jun 2 | 20:51 |
| John | Sheets, SD, OF | for | Hoo Lee, SF, OF | Free Replacement | Jun 2 | 20:32 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Happ, Chi, OF | for | Sheets, SD, OF | Activation from injured reserve | Jun 2 | 20:28 |
| John | Walker, SF, P | for | Tinoco, Chi, P | Free Replacement | Jun 2 | 20:27 |
| James | Irvin, Was, P | for | Smith-Shawver, Atl, P → IR | DL | May 30 | 14:50 |
| Tom | Ramírez, Mia, C | for | Rushing, LA, C | Free Replacement | May 30 | 11:56 |
| Levent | Sanchez, Mia, OF | for | Myers, Mia, OF | DL | May 30 | 07:59 |
| James | Bart, Pit, C | for | Amaya, Chi, C → IR | DL | May 29 | 18:00 |
| Tom | Palencia, Chi, P | for | Walker, SF, P | Free Replacement | May 28 | 16:49 |
| Ben | Bednar, Pit, P | for | Santana, Pit, P | Free Replacement | May 28 | 11:46 |
| Tom | Shaw, Chi, 3B | for | Espinal, Cin, 3B | Free Replacement | May 28 | 07:20 |
| James | Mikolas, StL, P | for | Abel, Phi, P | Minors | May 24 | 12:53 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Acuna Jr., Atl, DH | for | Fitzgerald, SF, DH | Activation from injured reserve | May 23 | 12:55 |
| Levent | Farmer, Col, SS | for | Edwards, Mia, SS → IR | DL | May 23 | 05:11 |
| James | Greene, Cin, P | for | Walker, Phi, P | Activation from injured reserve | May 22 | 10:23 |
| James | Abel, Phi, P | for | Yates, LA, P → IR | DL | May 19 | 12:30 |
| Tom | Strider, Atl, P | for | Gallen, Ari, P | Activation from injured reserve | May 19 | 11:29 |
| Ben | Fitzgerald, SF, DH | for | McCutchen, Pit, DH | Activation from injured reserve | May 18 | 15:39 |
| Tom | Miller, LA, P | for | Alvarado, Phi, P | Free Replacement | May 18 | 12:29 |
| James | Edman, LA, 2B | for | Kim, LA, 2B | Activation from injured reserve | May 18 | 11:22 |
| Ben | Meyer, Mia, P | for | Megill, NY, P | Free Replacement | May 18 | 08:58 |
| John | Henderson, Mil, P | for | Nola, Phi, P → IR | DL | May 17 | 18:23 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | Flores, SF, DH | for | Hays, Phi, DH | Free Replacement | May 17 | 05:14 |
| Levent | Norby, Mia, 3B | for | Wagaman, Mia, 3B | Free Replacement | May 17 | 05:10 |
| Levent | Baty, NY, 2B | for | Frazier, Pit, 2B | Free Replacement | May 17 | 05:06 |
| Levent | Brown, Chi, P | for | Irvin, Was, P | Free Replacement | May 17 | 04:54 |
| Levent | Martinez, Cin, P | for | Heaney, Pit, P | Free Replacement | May 17 | 04:51 |
| Levent | Romano, Phi, P | for | Bednar, Pit, P | Free Replacement | May 17 | 04:44 |
| James | Tovar, Col, SS | for | Acuna, NY, SS | Activation from injured reserve | May 16 | 21:22 |
| Tom | Rushing, LA, C | for | Ramírez, Mia, C | Free Replacement | May 16 | 10:58 |
| James | Kim, LA, 2B | for | Valdez, Pit, 2B | Free Replacement | May 15 | 13:50 |
| James | Baldwin, Atl, C | for | Bart, Pit, C | Free Replacement | May 15 | 13:47 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Sheets, SD, OF | for | Happ, Chi, OF → IR | DL | May 14 | 17:22 |
| James | Walker, Phi, P | for | Sasaki, LA, P → IR | DL | May 14 | 13:51 |
| Levent | Hays, Phi, DH | for | Crews, Was, DH | Activation from injured reserve | May 12 | 09:02 |
| John | Ruiz, Was, C | for | Bailey, SF, C | Free Replacement | May 11 | 13:40 |
| John | Hoo Lee, SF, OF | for | Walker, StL, OF | Free Replacement | May 11 | 13:39 |
| John | Tinoco, Chi, P | for | Pressly, Chi, P | Free Replacement | May 11 | 13:36 |
| James | Abbott, Cin, P | for | Vesia, LA, P | Free Replacement | May 11 | 13:34 |
| John | Cronenworth, SD, 2B | for | Mervis, Chi, DH | Activation from injured reserve | May 11 | 13:32 |
| John | Marte, Ari, 2B | for | Kiner-Falefa, Pit, SS | Activation from injured reserve | May 11 | 13:31 |
| James | Smith-Shawver, Atl, P | for | Abbott, Cin, P | Free Replacement | May 10 | 22:25 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Santana, Pit, P | for | Meyer, Mia, P | Free Replacement | May 10 | 12:49 |
| James | Rea, Mil, P | for | Greene, Cin, P → IR | DL | May 9 | 14:38 |
| Tom | Espinal, Cin, 3B | for | Marte, Cin, 3B → IR | DL | May 8 | 12:21 |
| James | Kelly, Ari, P | for | Imanaga, Chi, P → IR | DL | May 6 | 12:59 |
| James | Merrill, SD, DH | for | Call, Was, DH | Activation from injured reserve | May 5 | 22:37 |
| Levent | Myers, Mia, OF | for | Hoo Lee, SF, OF | Free Replacement | May 5 | 08:56 |
| Levent | Canning, NY, P | for | Ohtani, LA, P → IR | DL | May 5 | 08:42 |
| Tom | Walker, SF, P | for | Santana, Pit, P | Free Replacement | May 4 | 18:22 |
| Ben | McCutchen, Pit, DH | for | Fitzgerald, SF, DH → IR | DL | May 4 | 14:47 |
| James | Acuna, NY, SS | for | Edman, LA, 2B → IR | DL | May 4 | 11:01 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | Crews, Was, DH | for | Hays, Phi, DH → IR | DL | May 3 | 04:25 |
| Tom | Gonsolin, LA, P | for | Roupp, SF, P | Free Replacement | May 1 | 09:30 |
| Ben | Pages, LA, OF | for | Acuna Jr., Atl, OF → IR | DL | May 1 | 07:25 |
| Ben | Liberatore, StL, P | for | Woodruff, Mil, P → IR | DL | May 1 | 07:23 |
| Levent | Hodge, Chi, P | for | Walker, SF, P | Free Replacement | Apr 29 | 12:39 |
| Levent | Beck, Col, OF | for | Mitchell, Mil, OF | Free Replacement | Apr 29 | 12:23 |
| Levent | Hays, Phi, DH | for | Flores, SF, DH | Free Replacement | Apr 29 | 12:18 |
| Levent | Trevino, Cin, C | for | Ruiz, Was, C | Free Replacement | Apr 29 | 12:13 |
| Levent | Wagaman, Mia, 3B | for | Shaw, Chi, 3B | Minors | Apr 29 | 12:07 |
| Levent | Frazier, Pit, 2B | for | Lopez, Mia, 2B | Free Replacement | Apr 29 | 12:00 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | Irvin, Was, P | for | Hicks, SF, P | Free Replacement | Apr 29 | 10:51 |
| Levent | Heaney, Pit, P | for | Adam, SD, P | Free Replacement | Apr 29 | 10:47 |
| Tom | Ray, SF, P | for | Glasnow, LA, P → IR | DL | Apr 29 | 01:17 |
| Ben | Arraez, SD, 1B | for | Steer, Cin, 1B | Activation from injured reserve | Apr 28 | 21:29 |
| Ben | Steer, Cin, 1B | for | Sheets, SD, 1B | Free Replacement | Apr 27 | 19:18 |
| Tom | Marte, Cin, 3B | for | McMahon, Col, 3B | Free Replacement | Apr 27 | 08:43 |
| James | Valdez, Pit, 2B | for | Tovar, Col, SS → IR | DL | Apr 26 | 11:12 |
| Tom | Ramírez, Mia, C | for | Torrens, NY, C | Free Replacement | Apr 26 | 08:18 |
| Tom | Abrams, Was, SS | for | Ortiz, Mil, SS | Activation from injured reserve | Apr 24 | 20:32 |
| Ben | Stowers, Mia, OF | for | McCarthy, Ari, OF | Free Replacement | Apr 23 | 07:20 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Roupp, SF, P | for | Strider, Atl, P → IR | DL | Apr 21 | 23:34 |
| Ben | Megill, NY, P | for | Pallante, StL, P | Free Replacement | Apr 21 | 21:15 |
| Ben | Sheets, SD, 1B | for | Arraez, SD, 1B → IR | DL | Apr 21 | 20:55 |
| Levent | Bednar, Pit, P | for | Puk, Ari, P → IR | DL | Apr 21 | 02:39 |
| James | Abbott, Cin, P | for | Alcantara, Mia, P | Free Replacement | Apr 18 | 22:40 |
| Tom | Holmes, NY, P | for | Ray, SF, P | Free Replacement | Apr 17 | 11:03 |
| Ben | Muncy, LA, 3B | for | Steer, Cin, 1B | Free Replacement | Apr 17 | 09:47 |
| Ben | Fitzgerald, SF, DH | for | Muncy, LA, DH | Free Replacement | Apr 17 | 09:47 |
| James | May, LA, P | for | Holmes, NY, P | Free Replacement | Apr 15 | 10:10 |
| Ben | , | for | Steele, Chi, IR | Released from injured reserve | Apr 14 | 09:28 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Ortiz, Mil, SS | for | Abrams, Was, SS → IR | DL | Apr 13 | 22:10 |
| Ben | Pagan, Cin, P | for | Halvorsen, Col, P | Free Replacement | Apr 13 | 10:11 |
| John | Mervis, Chi, DH | for | Cronenworth, SD, DH → IR | DL | Apr 12 | 09:57 |
| James | Call, Was, DH | for | Crews, Was, DH | Free Replacement | Apr 11 | 22:44 |
| Ben | Meyer, Mia, P | for | Steele, Chi, P → IR | DL | Apr 10 | 13:31 |
| James | Yastrzemski, SF, OF | for | Merrill, SD, OF → IR | DL | Apr 9 | 17:34 |
| Levent | Adam, SD, P | for | Cortes, Mil, P → IR | DL | Apr 9 | 11:21 |
| John | Boyd, Chi, P | for | Snell, LA, P → IR | DL | Apr 9 | 11:19 |
| John | Kiner-Falefa, Pit, SS | for | Marte, Ari, 2B → IR | DL | Apr 9 | 11:18 |