| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Young, Was, OF | for | Hoo Lee, SF, OF → IR | DL | May 28 | 09:24 |
| Tom | Sasaki, LA, P | for | Alcantara, Mia, P | Free Replacement | May 28 | 06:05 |
| John | Senzatela, Col, P | for | Cabrera, Chi, P → IR | DL | May 26 | 11:42 |
| Tom | Suarez, Cin, DH | for | Ozuna, Pit, DH | Activation from injured reserve | May 26 | 10:15 |
| Ben | Steer, Cin, OF | for | Church, StL, OF → IR | DL | May 25 | 11:22 |
| Ben | Lovelady, Was, P | for | Varland, Was, P | Free Replacement | May 25 | 11:19 |
| Ben | Nunez, Was, OF | for | Moniak, Col, OF → IR | DL | May 23 | 13:11 |
| Mike | Strider, Atl, P | for | Lowder, Cin, P | Activation from injured reserve | May 22 | 16:20 |
| Ben | Webb, SF, P | for | Junk, Mil, P | Activation from injured reserve | May 21 | 10:39 |
| Ben | Amaya, Chi, C | for | Baldwin, Atl, C → IR | DL | May 19 | 20:46 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Acuna Jr., Atl, OF | for | Gurriel Jr., Ari, OF | Activation from injured reserve | May 19 | 17:51 |
| Tom | Henderson, Mil, P | for | Holmes, NY, P → IR | DL | May 19 | 08:24 |
| Ben | Church, StL, OF | for | O'Hearn, Pit, OF → IR | DL | May 17 | 23:03 |
| Levent | Sheets, SD, OF | for | Frelick, Mil, OF | Free Replacement | May 17 | 15:08 |
| Levent | Lee, Atl, P | for | Cavalli, Was, P | Free Replacement | May 17 | 15:02 |
| Levent | Brown, Chi, P | for | Painter, Phi, P | Free Replacement | May 17 | 14:56 |
| Levent | Schmitt, SF, DH | for | Caissie, Chi, DH | Free Replacement | May 17 | 14:39 |
| Levent | Ruiz, Was, C | for | Sanchez, Mil, C | Free Replacement | May 17 | 14:31 |
| Levent | Conforto, LA, OF | for | Dubón, Atl, OF | Free Replacement | May 17 | 14:29 |
| Levent | , | for | Taillon, Chi, IR | Released from injured reserve | May 17 | 14:05 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | , | for | Morel, Chi, IR | Released from injured reserve | May 17 | 14:04 |
| James | Rodriguez, Ari, P | for | Chandler, Pit, P | Free Replacement | May 16 | 18:46 |
| Ben | McCarthy, Col, OF | for | Church, StL, OF | Free Replacement | May 16 | 18:34 |
| Tom | Arenado, Ari, 3B | for | Suarez, Cin, 3B → IR | DL | May 16 | 09:15 |
| James | Vaughn, Mil, 1B | for | Arenado, Ari, 3B | Free Replacement | May 15 | 14:26 |
| James | Bleday, Cin, DH | for | Vaughn, Mil, DH | Free Replacement | May 15 | 14:25 |
| Ben | Buehler, SD, P | for | Singer, Cin, P | Free Replacement | May 13 | 12:08 |
| Ben | Mlodzinski, Pit, P | for | Patrick, Mil, P | Free Replacement | May 13 | 11:54 |
| James | Suarez, SD, P | for | Ritchie, Atl, P | Free Replacement | May 11 | 19:37 |
| Tom | Waldschmidt, Ari, OF | for | Steer, Cin, OF | Free Replacement | May 11 | 06:44 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Soto, Phi, P | for | Keller, Chi, P | Free Replacement | May 11 | 06:36 |
| John | Vasquez, SD, P | for | Walker, SF, P | Free Replacement | May 10 | 16:30 |
| John | Lodolo, Cin, P | for | Vasquez, SD, P | Activation from injured reserve | May 10 | 16:29 |
| Ben | Junk, Mil, P | for | Webb, SF, P → IR | DL | May 10 | 13:42 |
| Ben | Betts, LA, SS | for | Garcia Jr, Was, 2B | Activation from injured reserve | May 10 | 13:36 |
| James | McLain, Cin, 2B | for | Swanson, Chi, SS | Free Replacement | May 10 | 12:32 |
| John | Polanco, NY, DH | for | Smith, Was, 1B | Activation from injured reserve | May 9 | 15:28 |
| Ben | Varland, Was, P | for | Santillan, Cin, P | Free Replacement | May 9 | 14:23 |
| Ben | Santillan, Cin, P | for | Pagan, Cin, P → IR | DL | May 6 | 12:07 |
| Tom | , | for | Thielbar, Chi, IR | Released from injured reserve | May 6 | 11:07 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Palencia, Chi, P | for | Suarez, SD, P | Activation from injured reserve | May 6 | 11:03 |
| James | Gonzales, Pit, 2B | for | McLain, Cin, 2B | Free Replacement | May 5 | 22:43 |
| John | Roupp, SF, P | for | Kelly, Ari, P | Free Replacement | May 5 | 21:22 |
| John | Iglesias, Atl, P | for | Roupp, SF, P | Activation from injured reserve | May 5 | 21:20 |
| Tom | Gurriel Jr., Ari, OF | for | Acuna Jr., Atl, OF → IR | DL | May 5 | 10:18 |
| James | Vaughn, Mil, DH | for | Marsee, Mia, DH | Activation from injured reserve | May 4 | 23:55 |
| James | Rushing, LA, C | for | Ramirez, Mia, C | Minors | May 4 | 15:55 |
| Tom | Realmuto, Phi, C | for | Rushing, LA, C | Activation from injured reserve | May 3 | 21:24 |
| John | Hoo Lee, SF, OF | for | Crews, Was, OF | Minors | May 3 | 20:30 |
| John | McGreevy, StL, P | for | Woodruff, Mil, P → IR | DL | May 3 | 14:22 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Chourio, Mil, OF | for | Young, Was, OF | Activation from injured reserve | May 2 | 10:31 |
| James | Young, Was, OF | for | Robert, NY, OF → IR | DL | May 2 | 10:30 |
| James | Ritchie, Atl, P | for | Vesia, LA, P | Free Replacement | May 1 | 10:15 |
| Ben | Church, StL, OF | for | Friedl, Cin, OF | Free Replacement | Apr 30 | 09:09 |
| John | Hicks, Mia, C | for | Ford, Was, C | Minors | Apr 29 | 11:01 |
| Tom | Julien, Col, 2B | for | Stott, Phi, 2B | Free Replacement | Apr 27 | 10:57 |
| James | Arenado, Ari, 3B | for | Busch, Chi, 1B | Free Replacement | Apr 25 | 22:39 |
| Tom | Lopez, Mia, SS | for | Lindor, NY, SS → IR | DL | Apr 25 | 13:49 |
| Tom | Rushing, LA, C | for | Realmuto, Phi, C → IR | DL | Apr 25 | 00:13 |
| Tom | Suarez, SD, P | for | Thielbar, Chi, P → IR | DL | Apr 25 | 00:08 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Mike | Bauers, Mil, 1B | for | Marte, Cin, 3B | Minors | Apr 24 | 23:31 |
| Ben | Rumfield, Col, 1B | for | Bohm, Phi, 3B | Free Replacement | Apr 24 | 11:43 |
| Levent | Albies, Atl, 2B | for | Lopez, Mia, 2B | Activation from injured reserve | Apr 23 | 06:40 |
| Mike | Lowder, Cin, P | for | Strider, Atl, P → IR | DL | Apr 23 | 00:29 |
| Mike | Griffin, Was, P | for | Boyd, Chi, P | DL | Apr 23 | 00:28 |
| Mike | Mitchell, Mil, OF | for | Bader, SF, OF | DL | Apr 23 | 00:17 |
| James | Busch, Chi, 1B | for | Rumfield, Col, 1B | Free Replacement | Apr 22 | 21:55 |
| James | , | for | Horton, Chi, IR | Released from injured reserve | Apr 22 | 21:31 |
| James | Wrobleski, LA, P | for | Lopez, Atl, P | Free Replacement | Apr 22 | 21:30 |
| John | Roupp, SF, P | for | Iglesias, Atl, P → IR | DL | Apr 22 | 20:43 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Keller, Chi, P | for | Megill, Mil, P | Free Replacement | Apr 21 | 11:59 |
| Ben | Soto, NY, OF | for | Scott II, StL, OF | Activation from injured reserve | Apr 21 | 10:24 |
| Ben | Scott, LA, P | for | Diaz, LA, P → IR | DL | Apr 21 | 10:21 |
| John | Smith, Was, 1B | for | Polanco, NY, DH → IR | DL | Apr 19 | 21:36 |
| Tom | Thielbar, Chi, P | for | Palencia, Chi, P → IR | DL | Apr 19 | 20:05 |
| Tom | Holmes, NY, P | for | Senga, NY, P | Free Replacement | Apr 18 | 14:38 |
| Levent | Lopez, Mia, 2B | for | Albies, Atl, 2B → IR | DL | Apr 18 | 11:27 |
| James | Swanson, Chi, SS | for | Hamilton, Mil, SS | Free Replacement | Apr 17 | 19:12 |
| James | Vesia, LA, P | for | Beeter, Was, P | Free Replacement | Apr 15 | 10:27 |
| Levent | Caissie, Chi, DH | for | Yelich, Mil, DH → IR | DL | Apr 13 | 12:25 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | Elder, Atl, P | for | Pivetta, SD, P → IR | DL | Apr 13 | 12:21 |
| Levent | Dubón, Atl, OF | for | Doyle, Col, OF | Free Replacement | Apr 12 | 11:51 |
| Levent | Vargas, Ari, 3B | for | Arenado, Ari, 3B | Free Replacement | Apr 12 | 11:49 |
| Levent | O'Brien, StL, P | for | Pfaadt, Ari, P | Free Replacement | Apr 12 | 11:44 |
| Levent | Sanchez, Mil, C | for | Moreno, Ari, C → IR | DL | Apr 12 | 11:40 |
| James | Johnston, Mia, 1B | for | Busch, Chi, 1B | Free Replacement | Apr 10 | 16:37 |
| James | Hamilton, Mil, SS | for | Swanson, Chi, SS | Free Replacement | Apr 10 | 16:36 |
| James | Marsee, Mia, DH | for | Hamilton, Mil, DH | Free Replacement | Apr 8 | 19:22 |
| James | Rumfield, Col, 1B | for | Bauers, Mil, 1B | Free Replacement | Apr 8 | 19:15 |
| James | Walker, StL, OF | for | Marsee, Mia, OF | Free Replacement | Apr 8 | 19:10 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Moniak, Col, OF | for | Soto, NY, OF → IR | DL | Apr 6 | 17:08 |
| Ben | Garcia Jr, Was, 2B | for | Betts, LA, SS → IR | DL | Apr 5 | 17:21 |
| James | Lopez, Atl, P | for | Horton, Chi, P → IR | DL | Apr 4 | 10:23 |
| Levent | Griffin, Pit, SS | for | Garcia Jr, Was, 2B | Free Replacement | Apr 2 | 17:22 |
| James | Hamilton, Mil, DH | for | Castellanos, SD, DH | Free Replacement | Apr 1 | 22:56 |
| James | Soroka, Atl, P | for | Estrada, SD, P | Free Replacement | Mar 31 | 16:01 |
| John | Vasquez, SD, P | for | Lodolo, Cin, P → IR | DL | Mar 29 | 15:25 |
| Levent | Gorman, StL, 3B | for | Morel, Chi, 1B → IR | DL | Mar 29 | 13:47 |
| James | Bauers, Mil, 1B | for | Vaughn, Mil, 1B → IR | DL | Mar 28 | 20:02 |
| Ben | Scott II, StL, OF | for | Moniak, Col, OF | Free Replacement | Mar 28 | 08:52 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | Morel, Chi, 1B | for | Vientos, NY, 1B | Free Replacement | Mar 25 | 12:00 |
| Levent | Painter, Phi, P | for | Taillon, Chi, P → IR | DL | Mar 25 | 12:00 |
| James | Crawford, Phi, OF | for | Chourio, Mil, OF → IR | DL | Mar 25 | 12:00 |